Human Cancer Biology LINE-1 Hypomethylation, DNA Copy Number Alterations, and CDK6 Amplification in Esophageal Squamous Cell Carcinoma
نویسندگان
چکیده
Purpose: Global DNA hypomethylation plays a crucial role in genomic instability and carcinogenesis. DNA methylation of the long interspersed nucleotide element-1, L1 (LINE-1) repetitive element is a good indicator of the global DNA methylation level, and is attracting interest as a useful marker for predicting cancer prognosis. Our previous study using more than 200 esophageal squamous cell carcinoma (ESCC) specimensdemonstrated the significant relationship betweenLINE-1hypomethylation andpoor prognosis. However, themechanismbywhich LINE-1 hypomethylation affects aggressive tumor behavior has yet to be
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